TOPICAL PROTEASE INHIBITOR INCREASES TUMOR-FREE AND OVERALL SURVIVAL IN CD4-DEPLETED MOUSE MODEL OF ANAL CANCER

Topical Protease Inhibitor Increases Tumor-Free and Overall Survival in CD4-Depleted Mouse Model of Anal Cancer

Patients with immunodeficiencies and older age are at an increased risk of anal cancer.Transgenic K14E6/E7 mice with established high-grade anal dysplasia were treated topically at the anus with the protease inhibitor saquinavir (SQV) in the setting of CD4+ T-cell depletion to mimic immunodeficiency.To ensure tumor development, specific groups were

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Putting Temperature and Oxygen Thresholds of Marine Animals in Context of Environmental Change: A Regional Perspective for the Scotian Shelf and Gulf of St. Lawrence.

We conducted a literature review of reported temperature, salinity, pH, depth and oxygen preferences and thresholds AEG IWE41600KB INDUCTION WOK ACTIVE TOUCH of important marine species found in the Gulf of St.Lawrence and Scotian Shelf region.We classified 54 identified fishes and macroinvertebrates as important either because they support a comme

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